5-HTP Power
BENEFITS
• Improves sleep quality and duration.
• Supports the nervous system and enhances mood.
• May help decrease feelings of hunger.
HOW IT WORKS
5-HTP Power supports the nervous system by
promoting the production of serotonin. The body
converts 5-HTP into serotonin, an important neurotransmitter
responsible for mood, hunger and sleep.
NSP ADVANTAGE
• NSP is the only company whose 5-HTP product also
contains adaptogenic herbs that support the body
during times of change. All of these herbs have
ginseng-like properties that support the immune
system and speed the body’s recuperative processes.
• Some brands of 5-HTP contain more 5-HTP than our
product, leading some to wonder if 35 mg per capsule
is enough. Because the body excretes excess 5-HTP,
taking 35 mg at each meal is more effective than
taking one or two capsules of a higher potency product
at one time.
• Perhaps NSP’s strongest edge on the competition is the
addition of vitamin B6 and zinc. These two nutrients
prevent the conversion of 5-HTP into serotonin
while in the intestinal tract. Without these
nutrients, 5-HTP would be converted to
serotonin before it reached the brain, resulting in
no benefit to the brain.
Buck up … Slim down … Sleep better
… The "power" is yours.
• There is potential for 5-HTP to be contaminated with
a harmful substance known as peak X. NSP’s R&D
team uses the latest technology and state-of-the-art
instruments to ensure that our 5-HTP is free of this
contaminant.
INGREDIENTS
NSP blends its high-quality 5-HTP (hydroxytryptophan)
with three adaptogenic herbs—Eleuthero,
ashwaganda and suma. These herbs nourish the body and
enhance the beneficial effects of 5-HTP. This formula
also includes vitamin B6 and zinc, which strengthen the
bioavailability of 5-HTP.
RECOMMENDED USE
Each capsule contains 35 mg of 5-HTP. Take 1
capsule three times daily with a meal. As a sleep aid,
take 1–3 capsules with your evening meal. NSP
recommends a maximum of 3 capsules per day.
USER CARE
This product should not be taken by anyone using
prescription medication, or by pregnant or nursing women
without first consulting a qualified health-care practitioner.
NSP recommends taking a two-week break if you
desire to use 5-HTP Power for more than three months.
COMPLEMENTARY PRODUCTS
• Nutritional: St. John’s Wort, Time-Release Ginkgo,
Lecithin, Ginkgo/Gotu Kola Concentrate, High-
Potency Grapine®, Melatonin.
• Homeopathics: Distress Remedy, Depressaquel®.
• Essential Oils: Lavender Fine AOC, Geranium, Lemon
BIO, Red Mandarin.
040380JL
Contact your local NSP Herb Specialist:
These statements have not been evaluated by the Food and Drug Administration. www.naturessunshine.com
This product is not intended to diagnose, treat, cure or prevent any disease.
5-HTP Power (60)
No. de stock 2806-4
La alimentación moderna y la
falta de ejercicio incrementa el estrés,
contribuyendo a numerosos problemas
de sueño, ansiedad, depresión y
obesidad.. A causa de que los
fármacos por prescripción a menudo
vienen con efectos secundarios
indeseados, muchas personas buscan
apoyo en los suplementos naturales
saludables.
Gane control sobre su propia vida
con 5-HTP Power. Obtenga la fortaleza necesaria para
mejorar efectivamente su estado anímico, para tener
éxito en la pérdida de peso y para dormir mejor.
5-HTP Power
BENEFICIOS
• Mejora la calidad y duración del sueño.
• Apoya el sistema nervioso y mejora el estado
anímico.
• Puede ayudar a reducir el apetito.
CÓMO FUNCIONA
5-HTP Power apoya el sistema nervioso promoviendo
la producción de serotonina. El organismo convierte 5-
HTP en serotonina, un importante neurotransmisor,
responsable por el estado de ánimo, el apetito y el sueño.
LA VENTAJA DE 5-HTP POWER
• NSP es la única compañía que mejora los resultados de
5-HTP combinándolo con hierbas adaptogénicas que
apoyan al organismo durante la época de cambios. Todas
estas hierbas tienen propiedades similares al ginsén,
apoyan al sistema inmunológico y aceleran los procesos
de recuperación.
• Algunos productos de la competencia contienen mayor
cantidad de 5-HTP que nuestro producto, por lo que
algunas personas se preguntan si 35 mg por cápsula es
suficiente. Como el cuerpo elimina el exceso de 5-HTP, es
más efectivo tomar 35 mg en cada comida que tomar una
o dos cápsulas de una potencia mayor en una sola toma.
• Tal vez la mayor ventaja de NSP con relación a la
competencia es la adición de vitamina B6 y zinc.
Estos dos nutrientes realzan la conversión de 5- HTP
en serotonina en el sistema nervioso central.
Duerma mejor, pierda peso, gane tonicidad
• Existe el potencial de que el 5-htp se contamine con
una substancia conocida en el espectrómetro como
pico X. El Dpto. de Investigación y Desarrollo de
NSP usa la tecnología y los instrumentos más
modernos para asegurar que nuestro 5-HTP esté libre
de este contaminante.
INGREDIENTES
5-HTP de alta calidad (hidroxitriptófano) y tres
yerbas adaptogénicas: eleuthero, ashwaganda y suma.
Estas hierbas nutren el organismo y mejoran los efectos
beneficiosos de 5-HTP. Esta fórmula también incluye
vitamina B6 y zinc, los cuales fortalecen la biodisponibilidad
de 5-HTP.
RECOMENDACIÓN
Para mejorar el ánimo y perder peso, tome 1 cápsula
de 5-HTP Power 3 veces al día con comida. Como apoyo
para mejorar el sueño, tome de 1 a 3 cápsulas con la última
comida del día. No tomar más de 3 cápsulas diarias.
PRECAUCIÓN
Primero consulte con un profesional de la salud si
toma medicamentos por prescripción o si está embarazada
o dando de lactar. Tome un descanso de 2 semanas cada 3
meses si desea tomarlo por períodos prolongados.
PRODUCTOS COMPLEMENTARIOS
• Nutritivos: St. John’s Wort, Time-Release Ginkgo,
Lecithin, Ginkgo/Gotu Kola Concentrate, High-
Potency Grapine®, Melatonin.
• Homeopáticos: Distress Remedy, Depressaquel®.
• Aceites esenciales: Lavender Fine AOC, Geranium,
Lemon BIO, Red Mandarin.
040380JL
Su Especialista en Hierbas NSP es:
Estas afirmaciones no han sido evaluadas por la FDA. Este producto no está dirigido www.naturessunshine.com
para el diagnóstico, tratamiento, cura o prevención de ninguna enfermedad.
Friday, December 17, 2010
5-HTP FACT SHEET
What is 5-HTP & What Does it DO?
5-Hydroxytryptophan (5-HTP) is the intermediate between tryptophan and serotonin. It is used
by the body to make serotonin, an important substance for normal nerve and brain function.
Serotonin appears to play significant roles in sleep, emotional moods, pain control,
inflammation, intestinal peristalsis, and other body functions.1 Therefore, 5-HTP
supplementation may be helpful for symptoms associated with low serotonin levels, such as
emotional imbalances, sleeping problems, headaches, weight loss, and muscle aches and pains.7
Some more detailed information follows.
Emotional Imbalance: It has been shown that serotonin levels in individuals with depressed
feelings are considerably lower than those in normal subjects. Individuals who respond to 5-HTP
show a rise in serotonin levels similar to those with normal moods. Several studies have
demonstrated improvements in people who did not respond positively to mood boosting
prescription medications.2,7 A 5-HTP dose of 300 mg is sufficient in most cases of mood
imbalances, but in some cases a higher dosage may be necessary.7
Sleep: Several clinical studies have shown 5-HTP to produce good results in promoting and
maintaining sleep in normal subjects as well as in those experiencing sleeping problems. 5-HTP
may help increase REM sleep (typically about 25%), while simultaneously increasing deep sleep
stages 3 and 4 without increasing total sleep time.3,4 Although there is no clear dose-related
effect, a dosage of approximately 200 mg per day may be sufficient in most cases.7
Weight Loss: Serotonin influences eating behaviors. When people are fed tryptophan-free diets,
appetite is significantly increased, resulting in binge eating and carbohydrate cravings.
Researchers discovered that a carbohydrate meal causes more tryptophan to be delivered to the
brain, resulting in more serotonin being manufactured. This may be one reason why low
serotonin levels lead to “carbohydrate carvings” and may ultimately play a key role in the
development of obesity. 5-HTP may help to prevent the decline in serotonin levels associated
with a reduced calorie intake.5 A severe drop in serotonin leads to the brain putting out a strong
message to eat, which may help explain why most “diets” do not work.7 5-HTP may help
stimulate the satiety centers of the brain to discourage excess food consumption.7
5-HTP and L-Tryptophan Connection
5-HTP is not present in significant amounts in a typical diet. The human body manufactures 5-
HTP from L-tryptophan, a natural amino acid found in many dietary proteins. However, eating
food that contains tryptophan does not significantly increase 5-HTP levels.6 The protein in
almost all foods contains relatively small amounts of tryptophan and large proportions of other
amino acids, which compete for absorption. Therefore, consuming tryptophan-rich foods or just
high-protein foods in general does not result in high serotonin levels.7
In comparison studies 5-HTP often fairs better when compared to tryptophan as a supplement.
The proposed reason is the fact that 5-HTP easily crosses the blood-brain barriers and is not
affected by competing amino acids. 5-HTP also affects brain chemistry in a more broad and
positive fashion than the simple tryptophan supplement. Additionally, 5-HTP is one step further
on the path to serotonin synthesis. The conversion of tryptophan to 5-HTP by the enzyme
tryptophan hydrolase is the most important step in the conversion and is inhibited by a number
of factors, including stress, vitamin B6 deficiency, low magnesium, insensitivity to insulin,
various hormones, and genetic factors. Perhaps one of the best advantages of 5-HTP over
tryptophan is that it is safer. For example, taking tryptophan to produce positive effects in the
CF109 – Updated 6/03 2
treatment of emotional issues and sleeping problems requires a relatively high dose.
Furthermore, excessive levels of tryptophan can result in free radical activity8, which can harm
cellular structures.
Where Does it Come From? Supplemental 5-HTP is naturally derived from the seeds of the
Griffonia simplicifolia, a West African medicinal plant.
Dosage Suggestions: The dosage should start at 50 mg three times per day. If the response is
inadequate after 2 weeks, increase the dosage to 100 mg three times per day. This
recommendation will reduce the chances of experiencing the mild nausea that can accompany 5-
HTP supplementation. It can be taken with food.7
Possible Side Effects
Some health care professionals have speculated that consumption of 5-HTP may lead to what has
been termed "serotonin syndrome." The symptoms of which are dizziness, sweating, shivering,
confusion, diarrhea, muscle spasms, increased body temperature, flushing, and coronary artery
spasm and/or abnormal platelet aggregation, which are both risk factors for heart attack.
However, serotonin syndrome, a serious but uncommon condition, has not been reported to result
from supplementation with 5-HTP.9 Additionally, the level of intake at which this toxic effect
might if at all occur remains unknown. Although 5-HTP may theoretically lead to serotonin
syndrome, safety and efficacy studies10 do not support this theory, nor has the increased self-use
of 5-HTP indicated any serious safety problems with it.
Because of the theoretical concern that supplementing with 5-HTP could lead to the development
of serotonin syndrome it is recommended that anyone with cardiovascular disease, high blood
pressure, clotting problems, high levels of circulating triglycerides and other fats, and those at
risk for stroke to consult with a doctor before taking this product.
1 Guyton AC, Hall JE. Textbook of Medical Physiology, 9th ed. Philadelphia: W. B. Saunders, 1996.
2 Takahashi S., Kondo H. Kato N. Effect of L-5-hydrozytrypotopha on brain monoamine metabolism and evaluation
of its clinical effect in depressed patients. J Psychiatr Res 1975; 12: 177-187.
3 Wyatt RJ, Zarcone J, Engelman K. Effects of 5-HTP on the sleep of normal human subjects. Electroencephalogr
Clin Neurophysiol 1971; 30: 505-509.
4 Soulairac A, Lambinet H. Effect of 5-HTP, a serotoinin precursor, on sleep disorders. Ann Med Psychol. 1977; 1:
792-798.
5 Goodwin GM, Cowen PJ, Fairburn CG. Plasma concentrations of tryptophan and dieting. Br. Med J. 1990; 300:
1499-1500.
6 Healthnotes. Online, Inc. 1505 SE Gideon St., Suite 200, Portland, OR 97202, www.healthnotes.com. 1999.
Author are Lininger, Skye, D.C., Wright, Jonathan, M.D., Austin, Steve, N.D., Brown, Donald, N.D. & Gaby, Alan,
M.D. 5-HTP. 1999.
7 Murray, Michael. T & Pizzorno, Joseph. Textbook of Natural Medicine. Churchill Livingstone. 2000.
8 Aviram M, Cogan U, Mokady S. Excessive dietary tryptophan enhances plasma liquid peroxidation in rats.
Atherosclerosis. 1991; 88:29-43.
9 Martin TG. Serotonin syndrome. Ann Emerg Med 1996;28:520–6.
10 Byerley WF, Judd LL and others. "5-Hydroxytryptophan; A Review of its Antidepressant Efficacy and Adverse
Effects. J. Clin. Psychopharm. 7(3):127-.137 (1987).
5-Hydroxytryptophan (5-HTP) is the intermediate between tryptophan and serotonin. It is used
by the body to make serotonin, an important substance for normal nerve and brain function.
Serotonin appears to play significant roles in sleep, emotional moods, pain control,
inflammation, intestinal peristalsis, and other body functions.1 Therefore, 5-HTP
supplementation may be helpful for symptoms associated with low serotonin levels, such as
emotional imbalances, sleeping problems, headaches, weight loss, and muscle aches and pains.7
Some more detailed information follows.
Emotional Imbalance: It has been shown that serotonin levels in individuals with depressed
feelings are considerably lower than those in normal subjects. Individuals who respond to 5-HTP
show a rise in serotonin levels similar to those with normal moods. Several studies have
demonstrated improvements in people who did not respond positively to mood boosting
prescription medications.2,7 A 5-HTP dose of 300 mg is sufficient in most cases of mood
imbalances, but in some cases a higher dosage may be necessary.7
Sleep: Several clinical studies have shown 5-HTP to produce good results in promoting and
maintaining sleep in normal subjects as well as in those experiencing sleeping problems. 5-HTP
may help increase REM sleep (typically about 25%), while simultaneously increasing deep sleep
stages 3 and 4 without increasing total sleep time.3,4 Although there is no clear dose-related
effect, a dosage of approximately 200 mg per day may be sufficient in most cases.7
Weight Loss: Serotonin influences eating behaviors. When people are fed tryptophan-free diets,
appetite is significantly increased, resulting in binge eating and carbohydrate cravings.
Researchers discovered that a carbohydrate meal causes more tryptophan to be delivered to the
brain, resulting in more serotonin being manufactured. This may be one reason why low
serotonin levels lead to “carbohydrate carvings” and may ultimately play a key role in the
development of obesity. 5-HTP may help to prevent the decline in serotonin levels associated
with a reduced calorie intake.5 A severe drop in serotonin leads to the brain putting out a strong
message to eat, which may help explain why most “diets” do not work.7 5-HTP may help
stimulate the satiety centers of the brain to discourage excess food consumption.7
5-HTP and L-Tryptophan Connection
5-HTP is not present in significant amounts in a typical diet. The human body manufactures 5-
HTP from L-tryptophan, a natural amino acid found in many dietary proteins. However, eating
food that contains tryptophan does not significantly increase 5-HTP levels.6 The protein in
almost all foods contains relatively small amounts of tryptophan and large proportions of other
amino acids, which compete for absorption. Therefore, consuming tryptophan-rich foods or just
high-protein foods in general does not result in high serotonin levels.7
In comparison studies 5-HTP often fairs better when compared to tryptophan as a supplement.
The proposed reason is the fact that 5-HTP easily crosses the blood-brain barriers and is not
affected by competing amino acids. 5-HTP also affects brain chemistry in a more broad and
positive fashion than the simple tryptophan supplement. Additionally, 5-HTP is one step further
on the path to serotonin synthesis. The conversion of tryptophan to 5-HTP by the enzyme
tryptophan hydrolase is the most important step in the conversion and is inhibited by a number
of factors, including stress, vitamin B6 deficiency, low magnesium, insensitivity to insulin,
various hormones, and genetic factors. Perhaps one of the best advantages of 5-HTP over
tryptophan is that it is safer. For example, taking tryptophan to produce positive effects in the
CF109 – Updated 6/03 2
treatment of emotional issues and sleeping problems requires a relatively high dose.
Furthermore, excessive levels of tryptophan can result in free radical activity8, which can harm
cellular structures.
Where Does it Come From? Supplemental 5-HTP is naturally derived from the seeds of the
Griffonia simplicifolia, a West African medicinal plant.
Dosage Suggestions: The dosage should start at 50 mg three times per day. If the response is
inadequate after 2 weeks, increase the dosage to 100 mg three times per day. This
recommendation will reduce the chances of experiencing the mild nausea that can accompany 5-
HTP supplementation. It can be taken with food.7
Possible Side Effects
Some health care professionals have speculated that consumption of 5-HTP may lead to what has
been termed "serotonin syndrome." The symptoms of which are dizziness, sweating, shivering,
confusion, diarrhea, muscle spasms, increased body temperature, flushing, and coronary artery
spasm and/or abnormal platelet aggregation, which are both risk factors for heart attack.
However, serotonin syndrome, a serious but uncommon condition, has not been reported to result
from supplementation with 5-HTP.9 Additionally, the level of intake at which this toxic effect
might if at all occur remains unknown. Although 5-HTP may theoretically lead to serotonin
syndrome, safety and efficacy studies10 do not support this theory, nor has the increased self-use
of 5-HTP indicated any serious safety problems with it.
Because of the theoretical concern that supplementing with 5-HTP could lead to the development
of serotonin syndrome it is recommended that anyone with cardiovascular disease, high blood
pressure, clotting problems, high levels of circulating triglycerides and other fats, and those at
risk for stroke to consult with a doctor before taking this product.
1 Guyton AC, Hall JE. Textbook of Medical Physiology, 9th ed. Philadelphia: W. B. Saunders, 1996.
2 Takahashi S., Kondo H. Kato N. Effect of L-5-hydrozytrypotopha on brain monoamine metabolism and evaluation
of its clinical effect in depressed patients. J Psychiatr Res 1975; 12: 177-187.
3 Wyatt RJ, Zarcone J, Engelman K. Effects of 5-HTP on the sleep of normal human subjects. Electroencephalogr
Clin Neurophysiol 1971; 30: 505-509.
4 Soulairac A, Lambinet H. Effect of 5-HTP, a serotoinin precursor, on sleep disorders. Ann Med Psychol. 1977; 1:
792-798.
5 Goodwin GM, Cowen PJ, Fairburn CG. Plasma concentrations of tryptophan and dieting. Br. Med J. 1990; 300:
1499-1500.
6 Healthnotes. Online, Inc. 1505 SE Gideon St., Suite 200, Portland, OR 97202, www.healthnotes.com. 1999.
Author are Lininger, Skye, D.C., Wright, Jonathan, M.D., Austin, Steve, N.D., Brown, Donald, N.D. & Gaby, Alan,
M.D. 5-HTP. 1999.
7 Murray, Michael. T & Pizzorno, Joseph. Textbook of Natural Medicine. Churchill Livingstone. 2000.
8 Aviram M, Cogan U, Mokady S. Excessive dietary tryptophan enhances plasma liquid peroxidation in rats.
Atherosclerosis. 1991; 88:29-43.
9 Martin TG. Serotonin syndrome. Ann Emerg Med 1996;28:520–6.
10 Byerley WF, Judd LL and others. "5-Hydroxytryptophan; A Review of its Antidepressant Efficacy and Adverse
Effects. J. Clin. Psychopharm. 7(3):127-.137 (1987).
5-HTP (5-Hydroxytryptophan) vs. Prozac (SSRIs)
5-HTP (5-Hydroxytryptophan) vs. Prozac (SSRIs)
by Ward Dean, MD, James South, MA, and Jim English
Neurotransmitters are specialized biochemicals that nerve
cells use to 'talk' to each other. Serotonin is one of some
ten major brain neurotransmitters. Deficiencies of
serotonin in the brain have been linked to a number of
disparate conditions, including: depression (especially the
agitated, anxious, irritable type), (1-6) anxiety, (7) suicide,
(8) alcoholism, (9) violent behavior, (8) PMS, (10) obesity,
(10,11) compulsive gambling, (12) insomnia, (13)
carbohydrate craving, (10) SAD (seasonal affective
disorder), (10) and migraine headaches. (14)
Serotonin nerve circuits promote feelings of well-being,
calmness, personal security, relaxation, confidence and concentration. (15) Serotonin
circuits also help counterbalance the tendency of two other major neurotransmitters in
the brain — dopamine and noradrenaline — to encourage overarousal, fear, anger,
tension, aggression, violence, obsessive-compulsive actions, overeating, anxiety and
sleep disturbances. (15) Many people suffer from various degrees of brain serotonin
deficiency, leading to a host of mental, emotional and behavioral problems. To
understand why brain serotonin deficiency is becoming more common in modern
society, it is necessary to look at how the brain makes serotonin.
Serotonin Function
Serotonin (5HT), dopamine, and noradrenaline are the three main 'monoamine'
neurotransmitters — 'mono' because each one is made from a single, specific amino
acid. Serotonin is made from tryptophan, while dopamine and noradrenaline are made
from tyrosine and phenylalanine. Since the blood-brain barrier prevents serotonin from
being 'imported' from outside the brain, all serotonin used by our brain cells must be
made within the neurons. Normally the blood-brain barrier serves as a protective device
to prevent toxins from entering the brain. But this protection comes at a price — even
'friendly' molecules, such as amino acids needed by the brain, are limited by this barrier.
When nutrients are allowed to cross the blood-brain barrier they must be 'ferried' by
specialized transport molecules, much as passengers being transported on a bus. This
process creates a special 'bottleneck' for serotonin. Serotonin itself cannot pass through
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
the blood-brain barrier, while its precursor, tryptophan, must share its transport 'bus' with
five other amino acids — leucine, isoleucine, valine, tyrosine and phenylalanine.
In any normal diet, animal protein-based or vegetarian, tryptophan is the least plentiful of
all 20 food amino acids. Thus, tryptophan is typically outnumbered as much as 9:1 in its
competition to secure its transport through the blood-brain barrier into the brain. Eating a
high-protein diet in an attempt to increase dietary tryptophan (a typical diet provides only
1-1.5 grams/day) only increases its competition even more. Ironically, the only dietary
strategy that increases brain tryptophan supply is a high-carbohydrate, low-protein diet.
When large amounts of carbohydrates are eaten, the body secretes large amounts of
the hormone insulin to lower the resulting high blood sugar. In addition to lowering blood
sugar levels, insulin also clears most of the five amino acids that compete with
tryptophan for a 'ride' to the brain. The result is that tryptophan has the 'bus' to itself,
allowing plenty of tryptophan to reach the brain. (10)
Carbohydrates for Stress
This dietary strategy is instinctively known and practiced
by many Americans who eat large amounts of
carbohydrates, including candy, cake, pie, bread, chips,
ice cream, etc., when they are feeling stressed,
depressed or anxious. The resulting increase in brain
serotonin levels suppresses arousal and anxiety, and
promotes a (temporary) sense of well-being and security.
Unfortunately, this strategy comes at a high price. The
same insulin which enhances brain serotonin levels also
increases the conversion of the fats, carbohydrates and
amino acids cleared from the blood into stored body fat!
Hence the carbohydrate addiction/ obesity/serotonin
connection. (10)
Tryptophan vs. 5-HTP
In the 1970s, the American health food industry began to provide an alternative method
of getting more tryptophan to the brain -- tryptophan supplements. Many people found
that 500 to 3,000 mg of supplementary tryptophan daily provided practical relief from
depression, PMS, insomnia and obsessive-compulsive disorders. In 1989, the FDA
removed tryptophan from the American health food market due to a mysterious outbreak
of a rare but serious ailment -- eosinophilia myalgia (EMS). This EMS 'epidemic' was
later traced to a single batch of contaminated tryptophan from a Japanese producer.
Thirteen years later, although tryptophan has been proven to be safe (and is currently
available in baby food formulas, intravenous feeding solutions, and veterinary products)
the FDA still shows no signs of allowing tryptophan back onto the market as a dietary
supplement.
Fortunately, a safe, natural and effective alternative to tryptophan has been researched
for over 30 years. This substance is L-5-Hydroxytryptophan (5-HTP). 5-HTP is not
produced by bacterial fermentation (as was the tainted tryptophan) nor chemical
synthesis, but is extracted from the seeds of the Griffonia plant.
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
Tryptophan to Serotonin Conversion
When neurons convert tryptophan into serotonin, they must first use a vitamin B3-
dependent enzyme to convert tryptophan into 5-HTP. A vitamin B6-dependent enzyme is
then used to convert 5-HTP into serotonin. One researcher noted, 'There are several
advantages of considering L-5-HTP, as opposed to L-tryptophan, as being the major
determinant in elevating brain serotonin levels: L-5-HTP is not degraded by tryptophan
pyrrolase to kynurenine, the major pathway for peripheral degradation of L-tryptophan
(about 98 percent).
Furthermore, L-5-HTP easily crosses the blood-brain barrier ...' (1) Additionally, it should
be noted that 5-HTP is not incorporated into proteins, as is tryptophan; nor is 5-HTP
used to make vitamin B3, as is tryptophan. Thus, in comparison to tryptophan, 5-HTP is
virtually a 'guided missile' that is directly targeted to increasing brain serotonin levels.
Strikingly, some studies have shown better results using 200 to 300 mg of 5-HTP per
day as an antidepressant than other studies using 2000 to 3,000 mg or more of
tryptophan per day. (17)
A placebo-controlled, double-blind study reported in 1992 found excellent results treating
obesity using doses of 5-HTP as high as 900 mg daily, with minimal side effects (the
greatest side effect being diarrhea or upset stomach)! (11) In one study, the
antidepressant effects of 5-HTP was compared with fluvoxamine, a prescription Prozaclike
drug used in Europe. The 5-HTP patients showed slightly better treatment response
than the fluvoxamine group, yet had significantly fewer and less severe side effects. The
researchers note: 'Regarding tolerance and safety, however, oxitriptan [5-HTP] proved
superior to fluvoxamine as was apparent from a marked difference in severity of
untoward side effects between the two compounds. The study presented here ...strongly
confirm[s] the efficacy of 5-HTP as an antidepressant.' (4)
Prozac
In a society that has made the book Listening to Prozac a
mega-bestseller, some may still consider serotonin-selective
re-uptake inhibitor (SSRI) drugs such as Prozac the 'gold
standard' of managing the serotonin-deficiency syndrome,
even though the Poeldinger study showed 5-HTP to be
superior to a major SSRI, fluvoxamine. A study reported by
Risch and Nemeroff demonstrates, however, that even those
'successfully' treated with SSRIs (ignoring their frequent and sometimes serious side
effects) are dependent upon their brains’ producing adequate serotonin from either
tryptophan or 5-HTP.
SSRIs work by conserving existing brain serotonin supplies by keeping more serotonin
in the synaptic gap between neurons. They achieve this through preventing enzymatic
degradation of synaptic serotonin. SSRIs do not enhance serotonin production. Risch
and Nemeroff state: "...depressed patients were treated with low-tryptophan diets that
were supplemented with high doses of neutral amino acids [which compete with
tryptophan for transport through the blood-brain barrier]... Remitted depressed subjects
receiving serotonergic antidepressants (e.g. fluoxetine [Prozac], fluvoxamine) who were
challenged with low-tryptophan diet supplemented with neutral amino acids promptly
relapsed into severe clinical depression. When the tryptophan supplementation was
provided, the patients promptly recovered..." (3)
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
The many successful published studies using 5-HTP show that 5-HTP, by naturally
elevating brain serotonin, can alleviate the serotonin-deficiency syndrome without any
help from SSRI drugs. Yet the study related by Risch and Nemeroff eloquently shows
that the success of SSRI drugs is crucially dependent upon the brain producing
adequate serotonin (from either tryptophan or 5-HTP), and that brain serotonin
production is the controlling or rate-limiting variable underlying the apparent success of
SSRIs. It appears that the more logical and economically sound choice to alleviate
conditions that result from the serotonin deficiency syndrome is 5-HTP, the immediate
precursor of the deficient substance.
Satieté®
Curb your Appetite Enhance Mood Improve Sleep Quality
With its synergistic blend of herbs and amino acids,
Satieté® addresses many of today's most pressing health
concerns -- weight management, mood, and sleep.
Satieté® does this through one of its principal ingredients,
5-HTP (5-Hydroxytryptophan). 5-HTP is an amino acid
derivative and is the immediate precursor to serotonin, a
neurotransmitter involved in regulating mood, sleep,
appetite, energy level and sensitivity to pain. Low levels of
serotonin are associated with depression, anxiety, and
sleep disorders. The 5-HTP in Satieté® increases the
cell's production of serotonin, which boosts serotonin
levels.
One to two Satieté® taken 30-60 before meals causes satiety signals to be sent
to the brain earlier in the meal resulting in the consumption of fewer
calories. One to two Satieté taken 30-60 before bed may result in better sleep
patterns, significantly increasing the amount of time spent in REM or dream
sleep. Taken several times throughout the day, Satieté® often has a significant
positive effect on mood and sense of well-being.
References
1. K. Zmilacher, et al. L-5-Hydroxytryptophan Alone and in Combination with a Peripheral Decarboxylase Inhibitor in the
Treatment of Depression. Neuropsychobiology. 1988; 20: 28-35.
2. W. Byerley, et al. 5-Hydroxytryptophan: A Review of Its Antidepressant Efficacy and Adverse Effects. J Clin
Psychopharmacol 1987; 7: 127-37.
3. S. Risch and C. Nemeroff. Neurochemical Alterations of Serotonergic Neuronal Systems in Depression. J Clin
Psychiatry. 1992; 53: 3-7.
4. W. Poeldinger, et al. A Functional-Dimensional Approach to Depression: Serotonin Deficiency as a Target Syndrome in
a Comparison of 5 -Hydroxytryptophan and Fluvoxamine. Psychopathology. 1991; 24: 53-81.
5. H. van Praag. Management of Depression with Serotonin Precursors. Biol Psychiatry. 1981; 16: 291-310.
6. S Takahashi, et al. Effect of L-5-Hydroxytryptophan on Brain Monoamine Metabolism and Evaluation of Its Clinical
Effect in Depressed Patients. Psychiat Res 1975; 12: 177-87.
7. R. Kahn and H. Westenberg. L-5-Hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord, 1985; 8:
197-200.
8. V. Linnoila and M. Virkkunen. Aggression, Suicidality, and Serotonin. J Clin Psychiatry. 1992; 53: 46-51.
9. L. Buydens-Branchey, et al. Age of Alcoholism Onset. II. Relationship to Susceptibility to Serotonin Precursor
Availability. Arch Gen Psychiatry. 1989; 46: 231-36.
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
by Ward Dean, MD, James South, MA, and Jim English
Neurotransmitters are specialized biochemicals that nerve
cells use to 'talk' to each other. Serotonin is one of some
ten major brain neurotransmitters. Deficiencies of
serotonin in the brain have been linked to a number of
disparate conditions, including: depression (especially the
agitated, anxious, irritable type), (1-6) anxiety, (7) suicide,
(8) alcoholism, (9) violent behavior, (8) PMS, (10) obesity,
(10,11) compulsive gambling, (12) insomnia, (13)
carbohydrate craving, (10) SAD (seasonal affective
disorder), (10) and migraine headaches. (14)
Serotonin nerve circuits promote feelings of well-being,
calmness, personal security, relaxation, confidence and concentration. (15) Serotonin
circuits also help counterbalance the tendency of two other major neurotransmitters in
the brain — dopamine and noradrenaline — to encourage overarousal, fear, anger,
tension, aggression, violence, obsessive-compulsive actions, overeating, anxiety and
sleep disturbances. (15) Many people suffer from various degrees of brain serotonin
deficiency, leading to a host of mental, emotional and behavioral problems. To
understand why brain serotonin deficiency is becoming more common in modern
society, it is necessary to look at how the brain makes serotonin.
Serotonin Function
Serotonin (5HT), dopamine, and noradrenaline are the three main 'monoamine'
neurotransmitters — 'mono' because each one is made from a single, specific amino
acid. Serotonin is made from tryptophan, while dopamine and noradrenaline are made
from tyrosine and phenylalanine. Since the blood-brain barrier prevents serotonin from
being 'imported' from outside the brain, all serotonin used by our brain cells must be
made within the neurons. Normally the blood-brain barrier serves as a protective device
to prevent toxins from entering the brain. But this protection comes at a price — even
'friendly' molecules, such as amino acids needed by the brain, are limited by this barrier.
When nutrients are allowed to cross the blood-brain barrier they must be 'ferried' by
specialized transport molecules, much as passengers being transported on a bus. This
process creates a special 'bottleneck' for serotonin. Serotonin itself cannot pass through
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
the blood-brain barrier, while its precursor, tryptophan, must share its transport 'bus' with
five other amino acids — leucine, isoleucine, valine, tyrosine and phenylalanine.
In any normal diet, animal protein-based or vegetarian, tryptophan is the least plentiful of
all 20 food amino acids. Thus, tryptophan is typically outnumbered as much as 9:1 in its
competition to secure its transport through the blood-brain barrier into the brain. Eating a
high-protein diet in an attempt to increase dietary tryptophan (a typical diet provides only
1-1.5 grams/day) only increases its competition even more. Ironically, the only dietary
strategy that increases brain tryptophan supply is a high-carbohydrate, low-protein diet.
When large amounts of carbohydrates are eaten, the body secretes large amounts of
the hormone insulin to lower the resulting high blood sugar. In addition to lowering blood
sugar levels, insulin also clears most of the five amino acids that compete with
tryptophan for a 'ride' to the brain. The result is that tryptophan has the 'bus' to itself,
allowing plenty of tryptophan to reach the brain. (10)
Carbohydrates for Stress
This dietary strategy is instinctively known and practiced
by many Americans who eat large amounts of
carbohydrates, including candy, cake, pie, bread, chips,
ice cream, etc., when they are feeling stressed,
depressed or anxious. The resulting increase in brain
serotonin levels suppresses arousal and anxiety, and
promotes a (temporary) sense of well-being and security.
Unfortunately, this strategy comes at a high price. The
same insulin which enhances brain serotonin levels also
increases the conversion of the fats, carbohydrates and
amino acids cleared from the blood into stored body fat!
Hence the carbohydrate addiction/ obesity/serotonin
connection. (10)
Tryptophan vs. 5-HTP
In the 1970s, the American health food industry began to provide an alternative method
of getting more tryptophan to the brain -- tryptophan supplements. Many people found
that 500 to 3,000 mg of supplementary tryptophan daily provided practical relief from
depression, PMS, insomnia and obsessive-compulsive disorders. In 1989, the FDA
removed tryptophan from the American health food market due to a mysterious outbreak
of a rare but serious ailment -- eosinophilia myalgia (EMS). This EMS 'epidemic' was
later traced to a single batch of contaminated tryptophan from a Japanese producer.
Thirteen years later, although tryptophan has been proven to be safe (and is currently
available in baby food formulas, intravenous feeding solutions, and veterinary products)
the FDA still shows no signs of allowing tryptophan back onto the market as a dietary
supplement.
Fortunately, a safe, natural and effective alternative to tryptophan has been researched
for over 30 years. This substance is L-5-Hydroxytryptophan (5-HTP). 5-HTP is not
produced by bacterial fermentation (as was the tainted tryptophan) nor chemical
synthesis, but is extracted from the seeds of the Griffonia plant.
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
Tryptophan to Serotonin Conversion
When neurons convert tryptophan into serotonin, they must first use a vitamin B3-
dependent enzyme to convert tryptophan into 5-HTP. A vitamin B6-dependent enzyme is
then used to convert 5-HTP into serotonin. One researcher noted, 'There are several
advantages of considering L-5-HTP, as opposed to L-tryptophan, as being the major
determinant in elevating brain serotonin levels: L-5-HTP is not degraded by tryptophan
pyrrolase to kynurenine, the major pathway for peripheral degradation of L-tryptophan
(about 98 percent).
Furthermore, L-5-HTP easily crosses the blood-brain barrier ...' (1) Additionally, it should
be noted that 5-HTP is not incorporated into proteins, as is tryptophan; nor is 5-HTP
used to make vitamin B3, as is tryptophan. Thus, in comparison to tryptophan, 5-HTP is
virtually a 'guided missile' that is directly targeted to increasing brain serotonin levels.
Strikingly, some studies have shown better results using 200 to 300 mg of 5-HTP per
day as an antidepressant than other studies using 2000 to 3,000 mg or more of
tryptophan per day. (17)
A placebo-controlled, double-blind study reported in 1992 found excellent results treating
obesity using doses of 5-HTP as high as 900 mg daily, with minimal side effects (the
greatest side effect being diarrhea or upset stomach)! (11) In one study, the
antidepressant effects of 5-HTP was compared with fluvoxamine, a prescription Prozaclike
drug used in Europe. The 5-HTP patients showed slightly better treatment response
than the fluvoxamine group, yet had significantly fewer and less severe side effects. The
researchers note: 'Regarding tolerance and safety, however, oxitriptan [5-HTP] proved
superior to fluvoxamine as was apparent from a marked difference in severity of
untoward side effects between the two compounds. The study presented here ...strongly
confirm[s] the efficacy of 5-HTP as an antidepressant.' (4)
Prozac
In a society that has made the book Listening to Prozac a
mega-bestseller, some may still consider serotonin-selective
re-uptake inhibitor (SSRI) drugs such as Prozac the 'gold
standard' of managing the serotonin-deficiency syndrome,
even though the Poeldinger study showed 5-HTP to be
superior to a major SSRI, fluvoxamine. A study reported by
Risch and Nemeroff demonstrates, however, that even those
'successfully' treated with SSRIs (ignoring their frequent and sometimes serious side
effects) are dependent upon their brains’ producing adequate serotonin from either
tryptophan or 5-HTP.
SSRIs work by conserving existing brain serotonin supplies by keeping more serotonin
in the synaptic gap between neurons. They achieve this through preventing enzymatic
degradation of synaptic serotonin. SSRIs do not enhance serotonin production. Risch
and Nemeroff state: "...depressed patients were treated with low-tryptophan diets that
were supplemented with high doses of neutral amino acids [which compete with
tryptophan for transport through the blood-brain barrier]... Remitted depressed subjects
receiving serotonergic antidepressants (e.g. fluoxetine [Prozac], fluvoxamine) who were
challenged with low-tryptophan diet supplemented with neutral amino acids promptly
relapsed into severe clinical depression. When the tryptophan supplementation was
provided, the patients promptly recovered..." (3)
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
The many successful published studies using 5-HTP show that 5-HTP, by naturally
elevating brain serotonin, can alleviate the serotonin-deficiency syndrome without any
help from SSRI drugs. Yet the study related by Risch and Nemeroff eloquently shows
that the success of SSRI drugs is crucially dependent upon the brain producing
adequate serotonin (from either tryptophan or 5-HTP), and that brain serotonin
production is the controlling or rate-limiting variable underlying the apparent success of
SSRIs. It appears that the more logical and economically sound choice to alleviate
conditions that result from the serotonin deficiency syndrome is 5-HTP, the immediate
precursor of the deficient substance.
Satieté®
Curb your Appetite Enhance Mood Improve Sleep Quality
With its synergistic blend of herbs and amino acids,
Satieté® addresses many of today's most pressing health
concerns -- weight management, mood, and sleep.
Satieté® does this through one of its principal ingredients,
5-HTP (5-Hydroxytryptophan). 5-HTP is an amino acid
derivative and is the immediate precursor to serotonin, a
neurotransmitter involved in regulating mood, sleep,
appetite, energy level and sensitivity to pain. Low levels of
serotonin are associated with depression, anxiety, and
sleep disorders. The 5-HTP in Satieté® increases the
cell's production of serotonin, which boosts serotonin
levels.
One to two Satieté® taken 30-60 before meals causes satiety signals to be sent
to the brain earlier in the meal resulting in the consumption of fewer
calories. One to two Satieté taken 30-60 before bed may result in better sleep
patterns, significantly increasing the amount of time spent in REM or dream
sleep. Taken several times throughout the day, Satieté® often has a significant
positive effect on mood and sense of well-being.
References
1. K. Zmilacher, et al. L-5-Hydroxytryptophan Alone and in Combination with a Peripheral Decarboxylase Inhibitor in the
Treatment of Depression. Neuropsychobiology. 1988; 20: 28-35.
2. W. Byerley, et al. 5-Hydroxytryptophan: A Review of Its Antidepressant Efficacy and Adverse Effects. J Clin
Psychopharmacol 1987; 7: 127-37.
3. S. Risch and C. Nemeroff. Neurochemical Alterations of Serotonergic Neuronal Systems in Depression. J Clin
Psychiatry. 1992; 53: 3-7.
4. W. Poeldinger, et al. A Functional-Dimensional Approach to Depression: Serotonin Deficiency as a Target Syndrome in
a Comparison of 5 -Hydroxytryptophan and Fluvoxamine. Psychopathology. 1991; 24: 53-81.
5. H. van Praag. Management of Depression with Serotonin Precursors. Biol Psychiatry. 1981; 16: 291-310.
6. S Takahashi, et al. Effect of L-5-Hydroxytryptophan on Brain Monoamine Metabolism and Evaluation of Its Clinical
Effect in Depressed Patients. Psychiat Res 1975; 12: 177-87.
7. R. Kahn and H. Westenberg. L-5-Hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord, 1985; 8:
197-200.
8. V. Linnoila and M. Virkkunen. Aggression, Suicidality, and Serotonin. J Clin Psychiatry. 1992; 53: 46-51.
9. L. Buydens-Branchey, et al. Age of Alcoholism Onset. II. Relationship to Susceptibility to Serotonin Precursor
Availability. Arch Gen Psychiatry. 1989; 46: 231-36.
PO Box 271227 + Flower Mound, TX + 75027 + 1-800-803-0118 + www.fit4God.net
Ultra 5-HTP Formula
DESCRIPTION
Ultra 5-HTP Formula capsules, provided by Douglas Laboratories, contain a synergistic combination of 5-HTP, vitamins, minerals and other nutrients designed to support mood and a sense of well-being.
FUNCTIONS
Serotonin, an important brain neurotransmitter, is key in the regulation of appetite, mood, and melatonin production. The presence of serotonin in the brain is associated with a balanced emotional state. This is achieved in part by decreasing the activity of certain excitatory hormones, including dopamine and noradrenaline. Serotonin also acts as a satiety signal in the brain, thereby naturally regulating food intake. Additionally, as a precursor of melatonin, serotonin is involved in regulating sleep patterns.
As a metabolic intermediate in the conversion of tryptophan into serotonin, 5-HTP can also serve as a precursor of serotonin. 5-HTP offers a number of advantages over tryptophan. 5-HTP is derived naturally from the seeds of the Griffonia plant, unlike tryptophan which is produced synthetically or through bacterial fermentation. 5-HTP crosses into the brain more readily than tryptophan as it is able to cross the blood-brain barrier without competition for uptake. 5-HTP is significantly more effective than tryptophan; one 50 mg capsule of 5-HTP is roughly equivalent to 500 mg of tryptophan. Finally, research studies have shown 5-HTP to be safe at levels as high as 900 mg. As a result, 5-HTP is a safe and effective means of increasing brain serotonin levels.
As co-enzymes, the B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of lipids, carbohydrates, and proteins. B vitamins are also important for blood cells, hormones, and nervous system function. As water-soluble substances, B vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12). Therefore, the body needs an adequate supply of B vitamins on a daily basis.
Herbs such as St. John’s wort and Ginkgo biloba are widely recognized for their positive, supportive effects on mental and emotional function. Minerals such as magnesium, chromium and zinc play a wide variety of essential roles in the body and support optimum functioning of all the body’s processes.
Other nutrients such as L-Tyrosine, L-Glutamine and octacosanol are also included for their positive effects on mental and neurological well-being.
INDICATIONS
Ultra 5-HTP Formula may be a useful nutritional supplement for individuals wishing support healthy mental function and increase their levels of brain serotonin.
FORMULA (#85081)
Two vegetarian capsules contain:
Vitamin A.................................................1,000 I.U.
Vitamin C....................................................100 mg
Vitamin E.......................................................30 I.U.
Thiamine..........................................................5 mg
Riboflavin........................................................5 mg
Niacinamide...................................................50 mg
Folic Acid....................................................800 mcg
Vitamin B-12............................................1,000 mcg
Pantothenic Acid.............................................5 mg
Magnesium....................................................50 mg
(from Magnesium Aspartate complex)
Zinc................................................................10 mg
(from Zinc picolinate complex)
Chromium GTF...........................................100 mcg
(Chromium Polynicotinate)
5-HTP..........................................................125 mg
L-Tyrosine...................................................100 mg
L-Glutamine................................................100 mg
Octacosanol..............................................1,500 mcg
St. John’s Wort(standardized).......................30 mg
Ginkgo biloba(standardized).........................15 mg
(continued on reverse)
Inositol...........................................................25 mg
Pyridoxal-5-Phosphate...................................20 mg
SUGGESTED USE
Adults take 2 vegetarian capsules daily with meals or as directed by physician.
SIDE EFFECTS
No adverse side effects reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.
REFERENCES
Ahsan SK. Magnesium and cardiovascular diseases. J Indian Med Assoc 1997;95:185-8.
Alvarado R, Contreras S, Segovia-Riquelme N, Mardones J. Effects of serotonin uptake blockers and of 5-hydroxytryptophan on the voluntary consumption of ethanol, water and solid food by UChA and UChB rats. Alcohol 1990;7:315-9.
Angel I, Taranger MA, Claustre Y, Scatton B, Langer SZ. Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3H-mazindol binding in vitro. Life Sci 1988;43:651-8.
Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev 1998;3:271-80.
Blundell JE. Serotonin and appetite. Neuropharmacology 1984;23:1537-51.
Blundell JE, Leshem MB. The effect of 5-hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine. J Pharm Pharmacol 1975;27:31-7.
Cangiano C, Ceci F, Cairella M, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Rossi-Fanelli F. Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Adv Exp Med Biol 1991;294:591-3.
Preuss HG, Anderson RA. Chromium update: examining recent literature 1997-1998 [see comments]. Curr Opin Clin Nutr Metab Care 1998;1:509-12.
Raffa RB. Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. Life Sci 1998;62:L265-70.
Schmidt U, Sommer H. [St. John's wort extract in the ambulatory therapy of depression. Attention and reaction ability are preserved]. Fortschr Med 1993;111:339-42.
Staffeldt B, Kerb R, Brockmoller J, Ploch M, Roots I. Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatry Neurol 1994;7 Suppl 1:S47-53.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Manufactured by
Douglas Laboratories
600 Boyce Road
Pittsburgh, PA 15205
800-245-4440
PDS-85081 2004, Douglas Laboratories. All Rights Reserved
http://www.5htp100mg.com/
Ultra 5-HTP Formula capsules, provided by Douglas Laboratories, contain a synergistic combination of 5-HTP, vitamins, minerals and other nutrients designed to support mood and a sense of well-being.
FUNCTIONS
Serotonin, an important brain neurotransmitter, is key in the regulation of appetite, mood, and melatonin production. The presence of serotonin in the brain is associated with a balanced emotional state. This is achieved in part by decreasing the activity of certain excitatory hormones, including dopamine and noradrenaline. Serotonin also acts as a satiety signal in the brain, thereby naturally regulating food intake. Additionally, as a precursor of melatonin, serotonin is involved in regulating sleep patterns.
As a metabolic intermediate in the conversion of tryptophan into serotonin, 5-HTP can also serve as a precursor of serotonin. 5-HTP offers a number of advantages over tryptophan. 5-HTP is derived naturally from the seeds of the Griffonia plant, unlike tryptophan which is produced synthetically or through bacterial fermentation. 5-HTP crosses into the brain more readily than tryptophan as it is able to cross the blood-brain barrier without competition for uptake. 5-HTP is significantly more effective than tryptophan; one 50 mg capsule of 5-HTP is roughly equivalent to 500 mg of tryptophan. Finally, research studies have shown 5-HTP to be safe at levels as high as 900 mg. As a result, 5-HTP is a safe and effective means of increasing brain serotonin levels.
As co-enzymes, the B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of lipids, carbohydrates, and proteins. B vitamins are also important for blood cells, hormones, and nervous system function. As water-soluble substances, B vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12). Therefore, the body needs an adequate supply of B vitamins on a daily basis.
Herbs such as St. John’s wort and Ginkgo biloba are widely recognized for their positive, supportive effects on mental and emotional function. Minerals such as magnesium, chromium and zinc play a wide variety of essential roles in the body and support optimum functioning of all the body’s processes.
Other nutrients such as L-Tyrosine, L-Glutamine and octacosanol are also included for their positive effects on mental and neurological well-being.
INDICATIONS
Ultra 5-HTP Formula may be a useful nutritional supplement for individuals wishing support healthy mental function and increase their levels of brain serotonin.
FORMULA (#85081)
Two vegetarian capsules contain:
Vitamin A.................................................1,000 I.U.
Vitamin C....................................................100 mg
Vitamin E.......................................................30 I.U.
Thiamine..........................................................5 mg
Riboflavin........................................................5 mg
Niacinamide...................................................50 mg
Folic Acid....................................................800 mcg
Vitamin B-12............................................1,000 mcg
Pantothenic Acid.............................................5 mg
Magnesium....................................................50 mg
(from Magnesium Aspartate complex)
Zinc................................................................10 mg
(from Zinc picolinate complex)
Chromium GTF...........................................100 mcg
(Chromium Polynicotinate)
5-HTP..........................................................125 mg
L-Tyrosine...................................................100 mg
L-Glutamine................................................100 mg
Octacosanol..............................................1,500 mcg
St. John’s Wort(standardized).......................30 mg
Ginkgo biloba(standardized).........................15 mg
(continued on reverse)
Inositol...........................................................25 mg
Pyridoxal-5-Phosphate...................................20 mg
SUGGESTED USE
Adults take 2 vegetarian capsules daily with meals or as directed by physician.
SIDE EFFECTS
No adverse side effects reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.
REFERENCES
Ahsan SK. Magnesium and cardiovascular diseases. J Indian Med Assoc 1997;95:185-8.
Alvarado R, Contreras S, Segovia-Riquelme N, Mardones J. Effects of serotonin uptake blockers and of 5-hydroxytryptophan on the voluntary consumption of ethanol, water and solid food by UChA and UChB rats. Alcohol 1990;7:315-9.
Angel I, Taranger MA, Claustre Y, Scatton B, Langer SZ. Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3H-mazindol binding in vitro. Life Sci 1988;43:651-8.
Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev 1998;3:271-80.
Blundell JE. Serotonin and appetite. Neuropharmacology 1984;23:1537-51.
Blundell JE, Leshem MB. The effect of 5-hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine. J Pharm Pharmacol 1975;27:31-7.
Cangiano C, Ceci F, Cairella M, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Rossi-Fanelli F. Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Adv Exp Med Biol 1991;294:591-3.
Preuss HG, Anderson RA. Chromium update: examining recent literature 1997-1998 [see comments]. Curr Opin Clin Nutr Metab Care 1998;1:509-12.
Raffa RB. Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. Life Sci 1998;62:L265-70.
Schmidt U, Sommer H. [St. John's wort extract in the ambulatory therapy of depression. Attention and reaction ability are preserved]. Fortschr Med 1993;111:339-42.
Staffeldt B, Kerb R, Brockmoller J, Ploch M, Roots I. Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatry Neurol 1994;7 Suppl 1:S47-53.
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Manufactured by
Douglas Laboratories
600 Boyce Road
Pittsburgh, PA 15205
800-245-4440
PDS-85081 2004, Douglas Laboratories. All Rights Reserved
http://www.5htp100mg.com/
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